DYNAMIC BIODISTRIBUTION OF INHALED SILICA PARTICLES TO EXTRAPULMONARY SITES: EARLY AND LATE TRANSLOCATION MECHANISMS WITH IMPLICATION FOR PARTICLE BIOMONITORING

An innovative method based on inductively coupled plasma mass spectrometry (ICP-MS) was developed to quantify the time-dependent systemic redistribution pattern of pulmonary-deposited crystalline silica particles by measuring silicon (Si) levels in the lungs, distal organs, and biological fluids.The method was applied in a murine model and validate

Abstract In recent years, the reports of Kyasanur forest disease (KFD) breaking endemic barriers by spreading to new regions and crossing state boundaries is alarming.Effective disease surveillance and reporting systems are lacking for this emerging zoonosis, hence hindering control and prevention efforts.We compared time-series models using weathe

Abstract Background Microarray analysis allows the simultaneous measurement of thousands to millions of genes or sequences across tens to thousands of different samples.The analysis of the resulting data tests the limits of existing bioinformatics computing infrastructure.A solution to this issue is to use High Performance Computing (HPC) systems,

It is important to secure running safety of railway vehicles against wheel-climb derailment accidents.The safety is often discussed according to the value of derailment coefficients for the leading outside wheel of a railway bogie running on Queen Lifestyle Base sharp curves.Therefore, the detailed force induced mechanism which influences the value

Background With the rapid progress of genetic engineering and gene therapy methods, the World Anti-Doping Agency has raised concerns regarding gene doping, which is prohibited in sports.However, there is no standard method available for detecting transgenes delivered by injection of naked plasmids.Here, we developed a detection method for detecting